The new Solo Antibody-Drug Conjugate Single-Use isolator design incorporates advanced features like an automated pressure decay test prior to each start cycle. This will send the control panel into alarm if any leakage is detected across the entire flexible enclosure system. Due to the very low-level containment performance target, Solo realised that the Achilles heel of many flexible film isolation systems – enclosure change over needed special attention. With all 2019 designs from Solo, the HEPA filters and continuous liner ports are “single use” items. The safety factor was increased yet further by sequential automated valves enabling the entire contaminated flexible enclosure assembly to be collapsed by fan vacuum. This ensures the contaminated enclosure stays at negative pressure throughout the changeover period.